Unraveling GI Cancer Heterogeneity Through Single-Cell Multi-Omics Approaches

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May 21, 2026
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𝙴𝙳𝙸𝚃𝙾𝚁𝙸𝙰𝙻: 𝚄𝙽𝚁𝙰𝚅𝙴𝙻𝙸𝙽𝙶 𝙶𝙸 𝙲𝙰𝙽𝙲𝙴𝚁 𝙷𝙴𝚃𝙴𝚁𝙾𝙶𝙴𝙽𝙴𝙸𝚃𝚈 𝚃𝙷𝚁𝙾𝚄𝙶𝙷 𝚂𝙸𝙽𝙶𝙻𝙴-𝙲𝙴𝙻𝙻 𝙼𝚄𝙻𝚃𝙸-𝙾𝙼𝙸𝙲𝚂 𝙰𝙿𝙿𝚁𝙾𝙰𝙲𝙷𝙴𝚂

Our Editorial for the Frontiers Research Topic Unraveling GI Cancer Heterogeneity Through Single-Cell Multi-Omics Approaches has been published in Frontiers in Genetics.

📕 Jansen RJ, Bardini R and Grassi E (2026) Editorial: Unraveling GI cancer heterogeneity through single-cell multi-omics approaches. Front. Genet. 17:1869790. doi: 10.3389/fgene.2026.1869790

Beyond the paper itself, I am especially glad to have contributed to shaping this Research Topic, which highlights the potential of single-cell technologies and spatial transcriptomics to decode GI cancer heterogeneity.

Gastrointestinal cancers represent a major global health burden, accounting for 26% of cancer incidence and 35% of cancer-related deaths. Their clinical complexity is deeply linked to genetic and phenotypic heterogeneity, tumor microenvironment dynamics, and a recent worldwide increase in incidence among younger individuals.

These challenges are precisely what motivated the Research Topic, which brings together recent work exploring how single-cell technologies, spatial transcriptomics, and multi-omics approaches can help decode the complexity of GI cancers.

The collection brings together 7 articles and 21 authors, and has already reached 23.3K views.

🔗 Check it out: https://www.frontiersin.org/research-topics/63287/unraveling-gi-cancer-heterogeneity-through-single-cell-multi-omics-approaches/magazine

Many thanks to my co-editors, Rick Jansen and Elena Grassi, and to the Frontiers team, especially Catherine Swan and Elie Abdel Ahad, for their support throughout the process, as well as to the whole SMILIES Polito Research Group for supporting me in this endeavor.

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